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PDX List from gustave roussy. For more information contact Ludovic Bigot
PDX IdCohortHistologyDisease StatusTreatmentPrior treatmentMolecular DriverPhenotypeClinical HistoryMolecular CharacterizationParaffin BlockPharmaco Validation
Bellini_PDX1 BRAF Collecting duct (Bellini) Baseline CDDP + Gemcitabine + Bevacizumab BRAF:p.(Gly466Ala) Yes Panel Yes No
CB-01-002_PDX1 KRAS Lung Baseline Sotorasib Cispltine-Pemetrexed-Pembrolizumab, Carboplatin-Pemetrexed-Pembrolizumab, Pembrolizumab KRAS:p.(Gly12Cys) Yes WES-RNAseq Yes Yes
CB-01-003_PDX2 KRAS Lung Progressive disease Sotorasib Carboplatin-Pemetrexed-Pembrolizumab, Carboplatin-Paclitaxel-Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes No
CB-01-007_PDX1 KRAS Lung Baseline Sotorasib Carboplatin-Pemetrexed-Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes No
DSRCT-03_PDX1 other Prostate EWS::WT1 fusion No No Yes No
M2057_PDX1 FGFR Bladder Progressive disease Erdafitinib MVAC FGFR3:p.(Ser249Cys) Yes WES-RNAseq Yes Yes
M2267_PDX1 other NUT Midline Progressive disease BET inhibitor NUTM1 fusion Yes No Yes No
MR84_PDX1 prostate Prostate Primary resistance Enzalutamide Docetaxel TP53 deletion NEPC Yes WES-RNAseq Yes Yes
MR86_PDX1 FGFR Bladder Progressive disease Erdafitinib Cisplatin FGFR3:p.(Ser249Cys) Yes WES-RNAseq Yes Yes
MR86_PDX2 FGFR Bladder Stable disease Erdafitinib Cisplatin FGFR3:p.(Ser249Cys) Yes WES-RNAseq Yes Yes
MR10_PDX1 other Parotid gland Progressive disease NOTCH1 inhibitor Pazopanib, 5-FU-Cisplatin NOTCH1:p.(Ser2467*) Yes WES-RNAseq Yes Yes
MR1010_PDX1 EGFR Lung Progressive disease Osimertinib (first line) EGFR:p.(Leu858Arg) Yes WES-RNAseq Yes No
MR1016_PDX1 HER2 Lung Baseline Trastuzumab-deruxtecan Carboplatin-Pemetrexed-Pembrolizumab ERBB2:p.(Ala775_G776insTyrValMetAla) Yes WES-RNAseq Yes No
MR1025_PDX1 DDR Prostate Progressive disease Rucaparib Enzalutamide, Docetaxel BRCA2:p.(Cys2689fs*4) (germline), AR amplification Yes No Yes No
MR1029_PDX1 KRAS Lung Baseline Sotorasib Pemetrexed-Platin-Pembrolizumab KRAS:p.(Gly12Cys) Yes WES-RNAseq Yes Yes
MR1029_PDX2 KRAS Lung On treatment Sotorasib Pemetrexed-Platin-Pembrolizumab KRAS:p.(Gly12Cys) Yes WES-RNAseq Yes No
MR1029_PDX3 KRAS Lung Progressive disease Sotorasib Pemetrexed-Platin-Pembrolizumab KRAS:p.(Gly12Cys) Yes WES-RNAseq Yes Yes
MR103_PDX1 FGFR Bladder Progressive disease Erdafitinib Carboplatin, Docetaxel Yes WES-RNAseq Yes Yes
MR1030_PDX1 Anaplastic thyroid Thyroid Progressive disease CLEVER-1 inhibitor Rx-carboplatin-Paclitaxel TP53:p.(Arg280Thr) Yes WES-RNAseq Yes No
MR1031_PDX1 KRAS Lung Progressive disease Sotorasib Cisplatin-Pemetrexed, Carboplatin-Paclitaxel-Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes Yes
MR104_PDX1 FGFR Bladder Progressive disease Erdafitinib Cisplatin, Carboplatin, Gemcitabine FGFR3:p.(Ser249Cys) Yes WES-RNAseq Yes No
MR1055_PDX1 NTRK Lung Baseline Entrectinib Carboplatin-Etoposide-Atezolizumab, Carboplatin-Paclitaxel-Bevacizumab EML4::NTRK2 fusion, EGFR:p.(Leu858Arg) Yes WES-RNAseq Yes No
MR1108_PDX1 BRAF Thyroid Baseline Dabrafenib + Trametinib BRAF:p.(Val600Glu) Yes WES-RNAseq Yes No
MR1130_PDX1 KRAS Colon Baseline (primary resistance) JDQ443 + TNO155 FOLFOX-bevacizumab, LV5FU2-bevacizumab, FOLFIRI-bevacizumab, LONSURF-bevacizumab KRAS:p.(Gly12Cys) Yes WES-RNAseq Yes No
MR1148_PDX1 FGFR Cholangiocarcinoma Baseline FOLFOX, FOLFIRI, Cisplatin-Gemcitabine BICC1::FGFR2 fusion Yes WES-RNAseq Yes No
MR1154-R_PDX1 FGFR Pancreas Progressive disease Futibatinib (TAS-120), FOLFOX, FOLFIRI ,Gemcitabine FGFR2::CCSER2 fusion Yes WES-RNAseq Yes No
MR1156_PDX1 EGFR Lung Progressive disease Osimertinib EGFR:p.(Leu858Arg) Yes WES-RNAseq Yes No
MR1168_PDX1 NTRK Lung neuroendocrine Progressive disease Repotrectinib Etoposide-Carboplatin-immunotherapie, Repotrectinib, Etoposide-Carboplatin-Larotrectinib EML4::NTRK3 fusion Yes WES-RNAseq Yes No
MR1188_PDX1 ALK Lung Progressive disease Alectinib EML4::ALK fusion Yes WES-RNAseq Yes No
MR1197_PDX1 DDR Ovary Progressive disease Niraparib Carboplatin-avastin TP53:p.(Cys238Tyr), CDK12:p.(Leu636Phefs*4) Yes WES-RNAseq Yes No
MR122_PDX1 DDR Colon Progressive disease Ceralasertib + Carboplatin FOLFOX, FOLFIRI ATM:p.(Gln2811Ter) Yes WES-RNAseq Yes Yes
MR1220_PDX1 EGFR Lung Progressive disease Osimertinib EGFR:p.(Leu858Arg) Yes WES-RNAseq Yes No
MR123_PDX1 prostate Prostate Primary resistance Enzalutamide Docetaxel, Abiraterone, Cabazitaxel BRCA2 deletion Luminal Yes WES-RNAseq Yes Yes
MR1238_PDX1 HER2 Lung Progressive disease Trastuzumab-deruxtecan RX-Durvalumab,Carboplatin-Paclitaxel-Pembrolizumab, Navelbin ERBB2:p.(Ser310Phe), KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR1247_PDX1 KRAS Pancreas Baseline screenfail MCLA-128 FOLFIRINOX KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR1249_PDX1 KRAS Pancreas Baseline Trastuzumab-deruxtecan FOLFIRINOX, Gemcitabine, FOLFOX, Paclitaxel KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR1253_PDX1 EGFR Lung Baseline (sensitive) ADC TROP2 Osimertinib, Cisplatin + pemetrexed + pembrolizumab, Gemcitabine EGFR deletion exon 19 Yes WES Yes No
MR1257_PDX1 KRAS Pancreas Baseline Gemcitabine + Paclitaxel FOLFIRINOX KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR1259_PDX1 KRAS Pancreas Baseline screenfail MCLA-128 FOLFIRINOX, Gemcitabine, Paclitaxel KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR1271_PDX1 FGFR Duodenum Progressive disease Futibatinib (TAS-120) FOLFOX, FOLFIRI FGFR2::NEK1 fusion Yes WES-RNAseq Yes No
MR1274_PDX1 other Pancreas Baseline FOLFIRINOX, Gemcitabine-Paclitaxel STAT3:p.(Asp661Val) Yes WES-RNAseq Yes No
MR1284_PDX1 KRAS Pancreas Baseline Brigatinib Ceritinib KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR131_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib, Rociletinb EGFR:p.(Leu858Arg), EGFR p.(Thr790Met) Yes WES-RNAseq Yes Yes
MR135_PDX1 ALK Lung Progressive disease Lorlatinib Crizotinib EML4::ALK fusion Yes WES-RNAseq Yes Yes
MR135_PDX2 ALK Lung Progressive disease Lorlatinib Crizotinib EML4::ALK fusion Yes WES-RNAseq Yes Yes
MR14_PDX1 other Lung Progressive disease Everolimus Pemetrexed-Cisplatin MTOR:p.(Pro465Thr) Yes No Yes No
MR142_PDX1 other Adenoid cystic carcinoma Progressive disease NOTCH1 inhibitor Cisplatin-Navelbin NOTCH1:p.(Pro2465Argfs*11) Yes WES-RNAseq Yes Yes
MR144_PDX1 ALK Lung Progressive disease Brigatinib Crizotinib, Ceritinib EML4::ALK fusion Yes WES-RNAseq Yes Yes
MR15_PDX1 FGFR Bladder Progressive disease Erdafitinib MVAC FGFR3:p.(Ser249Cys) Yes WES-RNAseq Yes Yes
MR15_PDX2 FGFR Bladder Stable disease Erdafitinib MVAC FGFR3:p.(Ser249Cys) Yes WES-RNAseq Yes Yes
MR150_PDX1 prostate Prostate Primary resistance Abiraterone Docetaxel, Cabazitaxel, Carboplatin ATM:p.(Arg1466Pro) Luminal Yes WES-RNAseq Yes Yes
MR151_PDX1 prostate Prostate Progressive disease Enzalutamide CDK12:p.(Leu866Trp) Mixed Yes WES-RNAseq Yes No
MR156_PDX1 EGFR Lung Progressive disease Osimertinib Erlotinib, Gefitinib, Cisplatin, Pemetrexed EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes Yes
MR170_PDX1 prostate Prostate Primary resistance Abiraterone Enzalutamide, Carboplatin RB1 deletion NEPC Yes WES-RNAseq Yes Yes
MR174_PDX1 FGFR Cholangiocarcinoma Progressive disease Erdafitinib Gemcitabine-Sunitinib-Everolimus-FOLFIRI FGFR2:p.(Cys382Arg) Yes WES-RNAseq Yes Yes
MR178_PDX1 prostate Prostate Progressive disease Enzalutamide AR:p.(Leu702His), AR:p.(His790Arg), AR:p.(His875Tyr) Luminal Yes WES-RNAseq Yes No
MR182_PDX1 prostate Prostate Baseline Enzalutamide ATM:p.(Ile2998Argfs*9) (germline) Luminal Yes WES-RNAseq Yes No
MR182_PDX2 prostate Prostate Progressive disease Enzalutamide ATM:p.(Ile2998Argfs*9) (germline) Mixed Yes WES-RNAseq Yes No
MR191_PDX1 prostate Prostate Primary resistance Enzalutamide Carboplatin BRCA2:p.(Val2118_Glu2123delinsLeuThrGlnLysTrpLys), BRCA2:p.(Thr2125Asnfs*4) NEPC Yes WES-RNAseq Yes Yes
MR191_PDX2 prostate Prostate Baseline Enzalutamide Docetaxel, Carboplatin BRCA2:p.(Thr2125Asnfs*4) NEPC Yes WES-RNAseq Yes Yes
MR196_PDX1 EGFR Lung Progressive disease Erlotinib EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes No
MR202_PDX1 EGFR Lung Progressive disease Osimertinib Carboplatin-paclitaxel-bevacizumab, Pemetrexed, Erlotinib EGFR:p.(Leu858Arg), EGFR p.(Thr790Met) Yes WES-RNAseq Yes No
MR210_PDX1 ALK Lung Progressive disease Lorlatinib Cisplatin, Crizotinib, Ceritinib EML4::ALK fusion, ALK:p.(Cys1156Tyr) Yes WES-RNAseq Yes Yes
MR211_PDX1 EGFR Lung Progressive disease Erlotinib Gefitinib EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes Yes
MR221_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib EGFR deletion exon 19 Yes WES-RNAseq Yes No
MR228_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib, Afatinib EGFR deletion exon 19 Yes WES-RNAseq Yes Yes
MR240_PDX1 EGFR Lung Progressive disease Osimertinib Erlotinib EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes Yes
MR240_PDX2 EGFR Lung Progressive disease Brigatinib Erlotinib, Osimertinib EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes No
MR242_PDX1 EGFR Lung Progressive disease Osimertinib Cisplatin, Gefitinib, Erlotinib, Carboplatin, Afatinib EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes Yes
MR246_PDX1 FGFR Bladder Progressive disease Erdafitinib Gemcitabine-Oxaliplatine, Carboplatin FGFR3:p.(Ser249Cys) Yes WES-RNAseq Yes No
MR248_PDX1 FGFR Bladder Progressive disease Erdafitinib Atezolizumab FGFR3:p.(Tyr373Cys) Yes WES Yes Yes
MR260_PDX1 EGFR Lung Progressive disease Osimertinib Afatinib, Gefitinib EGFR deletion exon 19 Yes WES-RNAseq Yes No
MR283_PDX1 prostate Prostate Progressive disease Enzalutamide Enzalutamide AR amplification Mixed Yes WES-RNAseq Yes No
MR313_PDX1 FGFR Cholangiocarcinoma Progressive disease Pemigatinib FOLFIRINOX, FOLFIRI FGFR2::STRN4 Yes WES-RNAseq Yes Yes
MR320_PDX1 BRAF Lung Progressive disease Dabrafenib Cisplatin-Vinorelbin BRAF:p.(Val600Glu) Yes WES-RNAseq Yes Yes
MR322_PDX1 EGFR Lung Progressive disease Osimertinib EGFR deletion exon 19 Yes WES-RNAseq Yes No
MR332_PDX1 FGFR Cholangiocarcinoma Progressive disease Erdafitinib Docetaxel, Carboplatin, FOLFIRI FGFR2::BICC1 fusion Yes WES-RNAseq Yes Yes
MR341_PDX1 KRAS Lung Baseline Sotorasib Cisplatin + navelbin, Nivolumab, Carboplatin-Pemetrexed-Bevacizumab, Paclitaxel-Bevacizumab KRAS:p.(Gly12Cys) Yes WES-RNAseq Yes Yes
MR344_PDX1 ALK Lung Progressive disease Ceritinib Crizotinib EML4::ALK fusion Yes WES-RNAseq Yes Yes
MR347_PDX1 ALK Lung Progressive disease Ceritinib Cisplatin-pemetrexed, Crizotinib EML4::ALK fusion Yes WES-RNAseq Yes Yes
MR369_PDX1 FGFR Cholangiocarcinoma Progressive disease Pemigatinib Gemcitabine-Oxaliplatine FGFR2::INA fusion Yes WES-RNAseq Yes Yes
MR371_PDX2 FGFR Bladder Progressive disease Futibatinib (TAS-120) Atezolizumab, Erdafitinib FGFR3:p.(Tyr373Cys) Yes WES-RNAseq Yes No
MR387_PDX1 EGFR Lung Progressive disease Erlotinib EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes Yes
MR393_PDX1 EGFR Lung Progressive disease Osimertinib (first line) EGFR:p.(Leu858Arg) Yes WES-RNAseq Yes Yes
MR406_PDX1 FGFR Bladder Progressive disease Pemigatinib carboplatin-Gemcitabine-Pembrolizumab FGFR3:p.(Ser249Cys) Yes WES-RNAseq Yes No
MR41_PDX1 prostate Prostate Baseline Pre Abiraterone PTEN deletion Luminal Yes WES-RNAseq Yes Yes
MR411_PDX1 FGFR Bladder Progressive disease Pemigatinib carboplatin-Gemcitabine-Pembrolizumab FGFR3:p.(Tyr373Cys) Yes WES-RNAseq Yes No
MR415_PDX1 BRAF Appendix Progressive disease Vemurafenib Cetuximab, FOLFOX, FOLFIRI, LV5FU2 BRAF:p.(Val600Glu) Yes WES-RNAseq Yes No
MR41R_PDX1 ALK Unknown probably lung EML4::ALK, ALK:p.(Gly1202Arg), ALK:p.(Gly134Arg) No WES-RNAseq Yes No
MR432_PDX1 other DLBCL Progressive disease CMAK683X2101 EED inhibitor CHOP, DHAP, GEMOX, ICE, Nivolumab, anti CD37, CC122, GA101, Tazemetostat, r-caelyx-endoxan-methotrexate, CMAK683X2101 (inhibiteur de EED)  TP53:p.(Arg175His) Yes WES-RNAseq Yes No
MR436_PDX1 EGFR Lung Progressive disease Erlotinib EGFR:p.(Leu858Arg) Yes WES-RNAseq Yes No
MR441_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes Yes
MR445_PDX1 EGFR Lung Progressive disease Erlotinib Carboplatin EGFR deletion exon 19 Yes WES-RNAseq Yes Yes
MR448_PDX1 ALK Lung Progressive disease Lorlatinib Crizotinib, Alectinib, Brigatinib EML4::ALK fusion Yes WES-RNAseq Yes Yes
MR468_PDX1 ALK Lung Progressive disease Alectinib first line Lorlatinib EML4::ALK fusion Yes WES-RNAseq Yes No
MR478_PDX1 EGFR Lung Progressive disease Osimertinib (first line) EGFR deletion exon 19 Yes WES-RNAseq Yes No
MR480_PDX1 ALK Lung Progressive disease Lorlatinib Crizotinib, Cisplatin CD74::ROS1 fusion Yes WES-RNAseq Yes No
MR491_PDX1 EGFR Lung Progressive disease Osimertinib (first line) EGFR deletion exon 19 Yes WES-RNAseq Yes No
MR5_PDX1 KRAS Endometrial Progressive disease MEK inhibitor Carboplatin, Paclitaxel KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes Yes
MR503_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib EGFR deletion exon 19 Yes WES-RNAseq Yes No
MR513_PDX1 KRAS Pancreas Progressive disease Sotorasib FOLFIRINOX, FOLFIRI, Gemcitabine-Paclitaxel-FOLFOX KRAS:p.(Gly12Cys), Deletion RB1 Yes WES-RNAseq Yes No
MR527_PDX1 ALK Lung Progressive disease Lorlatinib Alectinib EML4::ALK fusion Yes WES-RNAseq Yes No
MR556_PDX2 EGFR Lung Progressive disease Osimertinib EGFR:p.(Gly719Ala), EGFR:p.(Glu709Ala) (cis) Yes WES-RNAseq Yes No
MR563_PDX1 BRAF Thyroid Progressive disease Dabrafenib + Trametinib BRAF:p.(Val600Glu) Yes WES-RNAseq Yes No
MR57_PDX1 ALK Lung Progressive disease Lorlatinib Crizotinib EML4::ALK, ALK:p.(Cys1156Tyr) Yes WES-RNAseq Yes Yes
MR577_PDX1 ALK Lung Progressive disease Lorlatinib EML4::ALK fusion Yes WES-RNAseq Yes No
MR587_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib, Cisplatin EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes Yes
MR59_PDX1 prostate Prostate Primary resistance Enzalutamide Docetaxel Deletion RB1 NEPC Yes WES-RNAseq Yes Yes
MR590_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib, Cisplatin EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes No
MR600_PDX1 ALK Lung Progressive disease Alectinib EML4::ALK fusion Yes WES-RNAseq Yes No
MR600_PDX2 ALK Lung Progressive disease Alectinib EML4::ALK fusion Yes WES-RNAseq Yes No
MR602_PDX1 FGFR Cholangiocarcinoma Progressive disease Futibatinib (TAS-120) FOLFOX, FOLFIRI, Gemcitabine-cipslatine, Docetaxel FGFR2::MITF fusion Yes WES-RNAseq Yes No
MR619_PDX1 ALK Cholangiocarcinoma Progressive disease Alectinib Gemcitabine-Cisplatin-Pembrolizumab, Nab-Paclitaxel-Gemcitabin STRN::ALK fusion Yes WES-RNAseq Yes Yes
MR622_PDX1 other NUT Midline Progressive disease BET inhibitor BRD4::NUTM1 fusion Yes WES-RNAseq Yes No
MR646_PDX1 FGFR Cholangiocarcinoma Progressive disease Futibatinib (TAS-120) Cisplatin-Gemcitabine,FOLFOX FGFR2::TACC2 fusion Yes WES-RNAseq Yes No
MR696_PDX1 DDR Ovary Progressive disease Niraparib Carboplatin-avastin RAD51C:p.(Ile244fs*9), TP53:p.(Arg248Trp) Yes No Yes No
MR7_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib, Erlotinib, Carboplatin, Cetuximab EGFR:p.(Leu858Arg) Yes WES-RNAseq Yes Yes
MR701_PDX1 FGFR Cholangiocarcinoma Baseline Futibatinib (TAS-120) FOLFOX, Gemcitabin-Cipslatin FGFR2::ZMYM4 fusion Yes WES-RNAseq Yes No
MR719_PDX1 FGFR Cholangiocarcinoma Baseline Futibatinib (TAS-120) FOLFOX, Cisplatin-Gemcitabin FGFR2::SORBS2 fusion Yes WES-RNAseq Yes No
MR723_PDX1 DDR Gynecological Progressive disease Olaparib Carboplatin-Paclitaxel, Carboplatin-Gemcitabine BRCA2 (germline) Yes No Yes No
MR748_PDX1 prostate Prostate Baseline Enzalutamide NCOR2:p.(Gln667Alafs*37), PTEN deletion, TP53:p.(Ser149Profs*21) Yes WES-RNAseq Yes No
MR759_PDX1 KRAS Ovary Progressive disease Trametinib Carboplatin-Docetaxel, Carboplatin-Doxorubicin-Bevacizumab, Carboplatin-Bevacuzimab+/-Atezolizumab, Doxorubicin KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR761_PDX1 KRAS Lung Baseline Sotorasib Cisplatin-Pemetrexed-Pembrolizumab KRAS:p.(Gly12Cys) Yes WES-RNAseq Yes Yes
MR77_PDX1 prostate Prostate Primary resistance Darolutamide Docetaxel, Enzalutamide, Abiraterone Mixed Yes WES-RNAseq Yes Yes
MR803_PDX1 Anaplastic thyroid Thyroid Baseline (sensitive) Dabrafenib + Trametinib Rx + Cisplatin-Adriamycine TP53:p.(Arg181His) Yes WES-RNAseq Yes No
MR820_PDX1 EGFR Lung Baseline Osimertinib Gefitinib EGFR deletion exon 19, EGFR:p.(Thr790Met) Yes WES-RNAseq Yes No
MR835_PDX1 KRAS Pancreas Baseline (primary resistance) IPH5201 +/- durvalumab +/- oleclumab FOLFIRINOX, FOLFIRI, Eryaspase-gemcitabine-abraxane KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR835_PDX2 KRAS Pancreas Baseline (primary resistance) IPH5201 +/- Durvalumab +/- Oleclumab FOLFIRINOX, FOLFIRI, Eryaspase-gemcitabine-abraxane KRAS:p.(Gly12Asp) Yes WES-RNAseq Yes No
MR847_PDX1 FGFR Cholangiocarcinoma Baseline Pemigatinib FOLFOX, Gemcitabine-Cisplatin FGFR2::PHC1 fusion Yes WES-RNAseq Yes No
MR869_PDX1 KRAS Lung Progressive disease Sotorasib Cisplatin-Pemetrexed-Pembrolizumab, Paclitaxel-Bevacizumab KRAS:p.(Gly12Cys) Yes WES-RNAseq Yes Yes
MR87_PDX1 BRAF Collecting duct (Bellini) Progressive disease Trametinib Cisplatin-Gemcitabine-Bevacizumab BRAF:p.(Gly466Ala) Yes WES-RNAseq Yes Yes
MR87_PDX2 BRAF Collecting duct (Bellini) Progressive disease Trametinib Cisplatin-Gemcitabine-Bevacizumab BRAF amplification Yes WES-RNAseq Yes No
MR876_PDX1 EGFR Lung Progressive disease Osimertinib EGFR deletion exon 19 Yes WES-RNAseq Yes No
MR886_PDX1 EGFR Lung Progressive disease Osimertinib Gefitinib EGFR:p.(Leu858Arg) Yes WES-RNAseq Yes No
MR892_PDX1 EGFR Lung Progressive disease Osimertinib Erlotinib EGFR deletion exon 19 Yes WES-RNAseq Yes No
MR9_PDX1 prostate Prostate Baseline Enzalutamide BRCA2:p.(Glu49*) Mixed Yes WES-RNAseq Yes Yes
MR9_PDX2 prostate Prostate Progressive disease Atezolizumab Enzalutamide BRCA2:p.(Glu49*) Mixed Yes WES-RNAseq Yes No
MR9_PDX3 prostate Prostate Progressive disease Olaparib Enzalutamide, Atezolizumab BRCA2:p.(Glu49*) NEPC Yes WES-RNAseq Yes No
MR90_PDX1 DDR Endometrial Stable disease ATR inhibitor Cisplatin, Paclitaxel, 5FU, Gemcitabine ATM:p.(Ser2146Thr), ATRX:p.(Asp333Tyr) Yes WES-RNAseq Yes Yes
MR902_PDX1 Anaplastic thyroid Thyroid Progressive disease CLEVER-1 inhibitor Cisplatin + Adriamycine + Rx TP53:p.(Phe134fs*38) Yes WES-RNAseq Yes No
MR97_PDX1 FGFR Ovary Progressive disease Erdafitinib Carboplatin, Pazopanib FGFR2::FAM160B1 fusion Yes WES-RNAseq Yes Yes
MR97_PDX2 FGFR Ovary Stable disease Erdafitinib Carboplatin, Pazopanib FGFR2::FAM160B1 fusion Yes WES-RNAseq Yes Yes
RET-IGR-01_PDX1 RET Lung Progressive disease Selpercatinib Pemetrexed-Carboplatin KIF5B:RET fusion Yes No Yes No
ST-0293_PDX1 KRAS Colon Progressive disease KRAS:p.(Gly12Cys) No No Yes No
ST-0899_PDX1 ALK Lung Progressive disease Brigatinib Alectinib EML4::ALK fusion Yes WES-RNAseq Yes No
ST2099_PDX1 KRAS Pleural Progressive disease Sotorasib Cisplatin-Navelbine, Carboplatin-Pemetrexed-Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes No
ST-2405_PDX1 FGFR Cholangiocarcinoma Progressive disease Gemcitabine-Cisplatin, FOLFOX FGFR2:p.(Leu776fs*6) Yes No Yes No
ST-2543_PDX1 FGFR Cholangiocarcinoma Progressive disease Gemcitabine-Cisplatin, FOLFOX FGFR2::KIAA1217 fusion Yes No Yes No
ST2577_PDX1 RET Thyroid Progressive disease Selpercatinib Iode 131, Lenvatanib RET::NCOA4 fusion Yes WES-RNAseq Yes No
ST-2726_PDX2 FGFR Cholangiocarcinoma Baseline Cisplatin-Gemcitabine, RLY-4008, FOLFOX, FOLFIRI, Paclitaxel FGFR2::PLEKHA4 fusion Yes No Yes No
ST-3075_PDX1 ROS1 Lung Progressive disease Letrozol, Exemestane, Anastrozole, Crizotinib SDC4::ROS1 fusion Yes No Yes No
ST-3227_PDX1 FGFR Pancreas Progressive disease FOLFIRINOX,FOLFIRI,LV5FU2,Carboplatin-gemcitabine FGFR2::INA fusion Yes No Yes No
ST-3498_PDX1 ALK Lung Progressive disease Alectinib (primary resistance) EML4::ALK fusion Yes WES-RNAseq Yes No
ST3511_PDX1 ROS1 Lung Baseline Cisplatin-Pemetrexed, Crizotinib, Lorlatinib, Carboplatin-Pemetrexed-Bevacizumab CD74::ROS1 fusion Yes WES-RNAseq Yes No
ST3511_PDX2 ROS1 Lung Progressive disease Cisplatin-Pemetrexed, Crizotinib, Lorlatinib, Carboplatin-Pemetrexed-Bevacizumab CD74::ROS1 fusion Yes No Yes No
ST-3973_PDX2 ALK Lung Progressive disease Lorlatinib Crizotinib EML4::ALK fusion Yes WES-RNAseq Yes No
ST4029_PDX1 Anaplastic thyroid Thyroid Baseline Carboplatin + Paclitaxel ASXL1:p.(Gly643fs*15), TP53:p.(Glu286Lys) Yes WES-RNAseq Yes No
ST-4036_PDX1 FGFR Cholangiocarcinoma Progressive disease Gemcitabine-Cisplatin, FOLFOX FGFR2::WAC fusion Yes No Yes No
ST-4070_PDX1 EGFR Lung Progressive disease Osimertinib + Selpercatinib EGFR deletion exon 19 No No Yes No
ST-4085_PDX1 EGFR Lung Progressive disease Lazertinib - Amivantamab Osimertinib EGFR deletion exon 19 Yes No Yes No
ST-4193_PDX1 FGFR Cholangiocarcinoma Progressive disease Gemcitabine-Oxaliplatin FGFR2:p.(Cys382Arg) Yes No Yes No
ST-4352_PDX1 EGFR Lung Progressive disease Osimertinib EGFR deletion exon 19, KRAS:p.(Gly12Asp) Yes No Yes No
ST-4451_PDX1 KRAS Lung Progressive disease Sotorasib Carboplatin-Paclitaxel-Pembrolizumab, Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes No
ST-4764_PDX1 KRAS Lung Baseline Carboplatin-pemetrexed-pembrolizumab, Carboplatin-pemetrexed, Docetaxel,Gemcitabine,Paclitaxel,SGNB6A-001 (intégrine 6) KRAS:p.(Gly12Cys) Yes No Yes No
ST-4772_PDX1 nectine-4 Bladder Baseline Avelumab, Carboplatin-Gemcitabine, Pembrolizumab FGFR3:p.(Arg248Cys) Yes No Yes No
ST-5010_PDX1 ALK Lung Baseline Cisplatin-Pemetrexed, Crizotinib, Lorlatinib, Carboplatin-pemetrexed-bevacizumab EML4::ALK fusion Yes No Yes No
ST-5010_PDX2 ALK Lung Progressive disease Cisplatin-Pemetrexed, Crizotinib, Lorlatinib, Carboplatin-pemetrexed-bevacizumab EML4::ALK fusion Yes No Yes No
ST-5013_PDX1 EGFR Lung Progressive disease Osimertinib EGFR:p.(Leu858Arg) Yes No Yes No
ST-5016_PDX1 KRAS Lung Baseline Sotorasib Cisplatin-vinorelbine-Rx, Durvalumab, Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes No
ST-5242_PDX1 FGFR Bladder Baseline MVAC, Pembrolizumab, Paclitaxel, Erdafitinib FGFR3:p.(Tyr373Cys) Yes No Yes No
ST-5469_PDX1 ALK Lung Baseline Alectinib,Lorlatinib, Cisplatin-Pemetrexed EML4::ALK fusion Yes No Yes No
ST-5472_PDX1 EGFR Lung Baseline Osimertinib Docetaxel EGFR:p.(Leu858Arg) Yes No Yes No
ST-5526_PDX1 nectine-4 Bladder Progressive disease Enfortumab vedotin Cisplatin-Gemcitabine, Carboplatin, Pembrolizumab TP53, RB1 Yes No Yes No
ST-5923_PDX1 EGFR Lung Progressive disease Osimertinib EGFR deletion exon 19 Yes No Yes No
ST-5979_PDX1 KRAS Cholangiocarcinoma Progressive disease Xeloda, Cisplatin-Durvalumab-Gemcitabine KRAS:p.(Gly12Cys) Yes No Yes No
ST-6105_PDX1 KRAS Lung Baseline Sotorasib Cisplatin-Pemetrexed-Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes No
ST-6201_PDX1 KRAS Lung Baseline Sotorasib Carboplatin-Pemetrexed-Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes No
ST-6263_PDX1 nectine-4 Bladder Baseline Cisplatin-Gemcitabine, Pembrolizumab TP53, RB1, PTEN Yes No Yes No
ST-6372_PDX1 KRAS Lung Baseline Sotorasib Carboplatin-Paclitaxel-Pembrolizumab KRAS:p.(Gly12Cys) Yes No Yes No
ST-6566_PDX1 EGFR Lung Progressive disease Osimertinib EGFR No No Yes No
ST-6598_PDX1 EGFR Lung Baseline Osimertinib EGFR No No Yes No
ST-6714_PDX1 KRAS Lung Baseline Sotorasib Cisplatin-vinorelbin, Cisplatin-Pemetrexed-Pembrolizumab, Dostarlimab-docetaxel, Docetaxel KRAS:p.(Gly12Cys) Yes No Yes No
ST-7018_PDX1 nectine-4 Bladder Baseline No No Yes No